aldosterone receptors การใช้

Aldosterone receptors are present on the epithelial cells of the distal nephron in the kidney.
These mineralocorticoids cross-react with the aldosterone receptor, activating it and raising blood pressure.
Blockade of the aldosterone receptor with spironolactone removed the ventricular arrhythmia predisposition in " Kcne3 "-/-mice.
Aldosterone receptor antagonists are not recommended as first-line agents for blood pressure, but spironolactone and eplerenone are both used in the treatment of heart failure and resistant hypertension.
The mineralocorticoid receptor is stimulated by both aldosterone and cortisol, but a mechanism protects the body from excess aldosterone receptor stimulation by glucocorticoids ( such as cortisol ), which happen to be present at much higher concentrations than mineralocorticoids in the healthy individual.